Arsenal travel to Naples with a two goal lead from the first leg thanks to goals from Aaron Ramsey and an own goal from Kalidou Koulibaly. The lack of an away goal could prove costly for Napoli who know they will need to score at least three times without reply if they are to progress in normal time.
Napoli have been struggling for form in recent weeks and they have won one of their last four matches in all competitions. The win came on the weekend in Serie A as Napoli defeated Chievo Verona 3-1 away from home.
However, Napoli lost the away leg of their previous match in the Europa League at Red Bull Salzburg 2-0 and still managed to come away with a win overall in the tie, so will remain hopeful. Trends show they have lost only one of their last sixteen home Europa League games and have won eleven on those matches, including each of the last two.
Napoli have scored two or more goals in five of their last seven home Europa League matches and kept a clean sheet in each of the last two.
Arsenal recorded a 1-0 win at Watford in the Premier League on Monday night although the performance was far from convincing against ten men. The Gunners are in the final Champions League qualifying place but could also play in the Champions League next season by winning the Europa League.
Arsenal have won five of their last seven Europa League games, losing two but both defeats have come away from home. They have lost each of their last two away Europa League matches, with defeats coming at BATE Borisov and Rennes.
Team news and Napoli are without the injured duo of Raul Albiol and Amadou Diawara. There could be a change in attack from the first leg, with Arkadiusz Milik coming into the team in place of Dries Mertens.
Arsenal travel without Rob Holding, Hector Bellerin and Danny Welbeck who are all injured. Lucas Torreira and Laurent Koscielny are rated as doubtful.
Napoli have it all to do if they are to turn this around while Arsenal can afford to slow the game down and hit the hosts on the break.
PREDICTION : NAPOLI 3-1
Accumulator Tip : Over 2.5 @ 1.60 @ BETKING